I Okeke, University of Ibadan - Pathogenic Lineages of Enteric Bacteria in Nigeria
Enteric pathogens such as diarrhoeagenic Escherichia coli and Salmonella enterica are important causes of childhood illness and death in African countries. The project aims to determine the contributions of two enteric pathotypes, enteroaggregative E. coli (EAEC) and Salmonella, using a case-control study design. The Project uses sequence-based methods to identify predominant diarrheagenic lineages of both pathotypes in Nigeria and elucidate their recent evolutionary history. Additionally the project uses sequence-based methods to subtype invasive isolates recovered during the period of the case-control study and determine whether Salmonella lineages recovered from invasive infections are associated with diarrhoea and/or carried asymptomatically by healthy individuals.