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Dr Katerina Artavanis-Tsakonas

Biography:

Katerina Artavanis-Tsakonas received a PhD from The London School of Hygiene and Tropical Medicine in London, working with Eleanor Riley on the role of NK cells in response to malaria, genetic polymorphisms of NK receptors and their correlation to inflammation. She did a Post-doc at Harvard/MIT with Hidde Ploegh working on mechanisms of antigen presentation and host-pathogen interactions within the endocytic pathway. As a Wellcome Trust Career Development Fellow at Imperial College she worked on the ubiquitin pathway in host-parasite interactions. In 2015, she became a Lecturer in Parasitology, in the Department of Pathology.

Departments and Institutes

Wellcome Trust Sanger Institute:

Research Interests

Interests:

What can parasite infections reveal about mammalian cell biology?
1)   Plasmodium falciparum:
a)   immunosuppression, 
b)   impaired antigen presentation
c)    Proteomic profiling of phagosomes (host receptors engaged-parasite recognition)
d)   Role of low complexity regions in antigen presentation and immune evasion
e)   Mechanisms of antigen internalization, processing and presentation

2)   Trichinella spiralis:

a)   myotube reprogramming,
b)   de-differentiation
c)    Proteomic screening of secreted proteins
d)   characterization of how each protein individually affects muscle cells can identify factors capable of impacting cell-cycle, angiogenesis, immunity
e)   Manipulation/regeneration of terminally differentiated cells

Collaborations:

1)     Faith Osier, KEMRI-Wellcome trust Programme, Kilifi

Between 2013 and 2018, the Centre supported collaborative partnerships and scientific training activities in basic biomedical and health-related research. This was achieved through coordinated cross-faculty research across departments and research institutes in Cambridge including The Wellcome Trust Sanger Institute