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Pathogen Evolution and Emerging Threats

Flu breaking out of an infected cellMicrobes are highly adaptive and can evolve rapidly, acquiring new virulence traits or evolving resistance to therapeutic drugs. Pathogens such as Ebola Virus can move from zoonotic sources into the human population, causing epidemic disease and challenging health care systems. The Centre’s focus on pathogen evolution makes these challenges a central component of our research efforts.

We have experts working on emerging pathogens, in both a veterinary and human context and we work closely with sites in the field using molecular surveillence as a key tool. The emergence and spread of antimicrobial resistance (AMR) poses a particular challenge.  Indeed AMR has been identified as a major threat to human health by the UK Chief Medical Officer and several of our groups work in this area. Find links to some of our programmes in these areas below.



Virus Research

Genotype to Phenotype Research


Image: Flu virus released from an infected cell. Credit: David Goulding, Wellcome Trust Sanger Institute



The Cambridge Centre for Global Health Research is funded by the Wellcome Trust. In close collaboration with The Wellcome Trust Sanger Institute, it supports researchers working in public health and tropical medicine to develop their careers, and foster interchange between institutions in the UK and those based in low- and middle-income countries.

The Review was established to produce analysis of the global problems of antimicrobial resistance (AMR), and  to propose concrete actions to tackle these internationally.